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| Correlation Analysis of Basic Research and Technological Innovation in Synthetic Biology |
| Zhang Xue1,2, Zhang Zhiqiang1,2, Chen Xiujuan1,2, Guo Chen3 |
1.Chengdu Library and Information Center, Chinese Academy of Sciences, Chengdu 610041
2.Department of Library, Information and Archives Management, School of Economics and Management, University of Chinese Academy of Sciences, Beijing 100190
3.School of Information Management, Wuhan University, Wuhan 430072 |
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Abstract This study discusses the relationship between basic research and technological innovation in the field of synthetic biology based on a cross-reference analysis of papers and patents, provides suggestions for improving the ability of basic research and technological innovations in this field, and supports the integration strategy of scientific and technological resources. Academic papers and patents are used as the substitute indicators of basic research and technological innovation. A total of 9033 papers and 5233 patents collected from the Web of Science and United States patent and trademark office are used as the research object. In order to comprehensively analyze the relationship between basic research and technological innovation in the field of synthetic biology, we analyze patent and paper citations from four perspectives: the overall distribution of citations, scientific and technical linkage, the time lag of citations, and the cycle time; and we analyze the topic distribution from the paper-patent mixed citation. Approximately 97% of technological innovations in the field of synthetic biology around the globe have cited the theoretical results of basic research, while only 4% of basic research have cited the technological innovations. The overall fluctuation of the science linkage is not volatile, but the technology linkage has not exhibited a stable trend. The science linkage and technology linkage of the United States are better than those of other countries, while that of China is relatively backward. The patents are more likely to cite other patents with a time lag of less than 15 years and papers with a time lag of less than 13 years. The papers are more likely to cite patents with a time lag of less than 6 years and papers with a time lag of less than 6 years. The technical cycle and scientific cycle of a patent are 13.92 and 12.28 years, respectively, while those of a paper are 10.85 and 6.99 years, respectively. Basic research in the field of synthetic biology shows a development trend similar to that of technological innovations; for example, both focus on the synthesis of genes and genomes, gene editing, and other aspects of research, while the basic research focuses on more areas and fields. Therefore, in the future, strengthening the application of technological innovation results in basic research and promoting the output of new technological innovation results are necessary. Accelerating the speed of transformation from basic research as well as previous technological innovations and citing the highly innovative results of basic research and technological innovations are vital for promoting innovation.
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Received: 04 April 2019
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